Anticholesterol activity of ethanol extract of Ranti Hitam (Solanum blumei Nees ex Blume) Leaves: In vivo and In silico study
نویسندگان
چکیده
Ranti Hitam known as local name of ( Solanum blumei Nees ex Blume) found in the Dairi, Sumatera Utara, Indonesia. It is used by community traditional medicine which contains various phytochemical constituent steroidal alkaloids β2-solanin, diosgenin, flavonoids, saponins and tannins. The purpose study was to investigate anticholesterol activity ethanol extract vivo insilico methods. A number 15 rats were divided into 5 treatment groups high fat diet model, otherwise carried out determine main compound S. inhibiting HMG Co-A reductase. bioactive compounds , diosgenin (C 26 H 39 O 4 ) β2-solanine 63 NO 11 showed inhibition HMG-CoA reductase silico invivo test it indicated that 2 had activity.
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ژورنال
عنوان ژورنال: ????????
سال: 2022
ISSN: ['2411-6076', '2709-135X']
DOI: https://doi.org/10.3897/pharmacia.69.e84913